6-(4-PHENYL-BENZYLOXY-METHYL) GUVACINE - SYNTHESIS, GABA UPTAKE INHIBITOR AND MUSCARINIC PROPERTIES

Authors
BISEL P GIES JP SCHLEWER G WERMUTH CG
Citation
P. Bisel et al., 6-(4-PHENYL-BENZYLOXY-METHYL) GUVACINE - SYNTHESIS, GABA UPTAKE INHIBITOR AND MUSCARINIC PROPERTIES, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 3025-3028
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
24
Year of publication
1996
Pages
3025 - 3028
Database
ISI
SICI code
0960-894X(1996)6:24<3025:6G-SGU>2.0.ZU;2-G
Abstract
6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly t he compound was devoid of the gamma-aminobutyric acid (GABA) uptake in hibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M(1) and M(2) receptors. Copyright (C) 1 996 Elsevier Science Ltd