Using the weakly guiding approximation, and with the assumption that t
he nonlinearities are sufficiently weak so as not to change the transv
erse mode profile, perturbation theory is used to derive simple expres
sions for evaluating the modal, or effective, non-linear coefficients
of optical waveguide structures based on the non-linear coefficients o
f the constituent materials. In particular, the third-order and fifth-
order optical non-linearities of refraction and absorption are discuss
ed. The expressions are used to estimate the effective modal non-linea
r refraction coefficients for various types of slab waveguides, focusi
ng primarily on femtosecond refractive non-linearities in semiconducto
r amplifiers, including quantum-well structures. The results are of pa
rticular relevance to the design of all-optical switches based on thes
e effects.