HETEROCYCLO-SUBSTITUTED SULFA DRUGS .10. NOVEL 5-IMINO-DELTA(2)-PYRAZOLIN-4-DITHIOCARBAMYL-AZO DYES AS ANTIMICROBIAL AGENTS

Synthesis of a series of novel azo-sulfa drugs as yl-1-phenyl-Delta(2) -pyrazolin-4-dithiocarbamy-azo dyes (I-XV) are described via a reactio n of 4-sulfamoyl and/or sulfonyl diazonium chloride with 5-imino-3-met hyl 1-1-phenyl-Delta(2)-pyrazolin-4-dithiocarbam acid in acid medium. The corresponding iron, copper, mercury, cobalt, nickel, and lead chel ates were obtained in 1:1 ligand-to-metal cation molar ratio at ice te mperature as monochelate compounds (Iaf-XVaf). Furthermore, heating in 1:2 molar ratio gave di-chelate compounds (I'a-f-XV'a-f). All the syn thesized azo-sulfa drugs (ligands) and their mono- and/or di-chelates were characterized by microanalysis, UV,IR and H-NMR spectroscopy and were screened in vitro for their antibacterial and antifungal activiti es.