SYNTHESIS AND PHARMACOLOGICAL PROFILE OF SOME CHLOROXANTHONE-1,4-DIHYDROPYRIDINE DERIVATIVES

Authors
BISI A BUDRIESI R RAMPA A FABBRI G CHIARINI A VALENTI P
Citation
A. Bisi et al., SYNTHESIS AND PHARMACOLOGICAL PROFILE OF SOME CHLOROXANTHONE-1,4-DIHYDROPYRIDINE DERIVATIVES, Arzneimittel-Forschung, 46(9), 1996, pp. 848-851
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
46
Issue
9
Year of publication
1996
Pages
848 - 851
Database
ISI
SICI code
0004-4172(1996)46:9<848:SAPPOS>2.0.ZU;2-B
Abstract
A series of xanthone-1,4-dihydropyridine derivatives bearing a chlorin e atom in the xanthone nucleus was prepared. The compounds were evalua ted for inotropic, chronotropic and calcium antagonist properties. The chlorine introduction in the xanthone moiety slightly affected affini ty for cardiac vs. vascular tissues improving to some extent selectivi ty.