SYNTHESIS OF SOME 2-ARYLPROPIONIC ACID-AMIDES AS PRODRUGS

The synthesis of amide prodrugs of some 2-arylpropionic acids (ibuprof en, naproxen, diclofenac and ketorolac) and the enantiomeric separatio n of these compounds are reported in this paper. The compounds were pr epared from the corresponding 2-arylpropionic acids and (R-(-)-2-amino -1-butanol in the presence of N,N'-dicyclohexylcarbodiimide (DCC). Ena ntiomers were separated by preparative chromatography or crystallisati on. The structure were confirmed by infrared, nuclear magnetic resonan ce and elementary analysis. The compounds prepared in the study have s ignificant analgesic activity.