IN-VITRO CYTOGENETIC ANALYSIS OF THE EFFECTS OF OXYTOCIN ON HUMAN PERIPHERAL-BLOOD LYMPHOCYTES

Authors
DJELIC N SOLDATOVIC B ANDJELKOVIC M CVETKOVIC D
Citation
N. Djelic et al., IN-VITRO CYTOGENETIC ANALYSIS OF THE EFFECTS OF OXYTOCIN ON HUMAN PERIPHERAL-BLOOD LYMPHOCYTES, Mutation research, 356(2), 1996, pp. 265-268
Citations number
11
Categorie Soggetti
Genetics & Heredity",Biology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research → ACNP
ISSN journal
00275107
Volume
356
Issue
2
Year of publication
1996
Pages
265 - 268
Database
ISI
SICI code
0027-5107(1996)356:2<265:ICAOTE>2.0.ZU;2-I
Abstract
The purpose of this study was to determine possible genotoxic and cyto toxic (or mitogenic) effects of high concentrations of oxytocin, activ e component of Syntocinon(R) in cultures of human peripheral blood lym phocytes. Two test systems were used: (1) analysis of numerical and st ructural chromosome aberrations, and (2) the in vitro sister chromatid exchange (SCE) test. On the basis of the results obtained it can be c oncluded that oxytocin does not express any genotoxical properties. Fu rthermore, the mitotic index did not change significantly.