THE SEPARATION OF THE COMPLEMENTARY STRANDS OF DNA IN THE PRESENCE OFDNA TOPOISOMERASES

Authors
SIKORAV JL
Citation
Jl. Sikorav, THE SEPARATION OF THE COMPLEMENTARY STRANDS OF DNA IN THE PRESENCE OFDNA TOPOISOMERASES, Comptes rendus de l'Academie des sciences. Serie II. Mecanique, physique, chimie, astronomie, 323(5), 1996, pp. 329-333
Citations number
13
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Comptes rendus de l'Academie des sciences. Serie II. Mecanique, physique, chimie, astronomie → ACNP
ISSN journal
12518069
Volume
323
Issue
5
Year of publication
1996
Pages
329 - 333
Database
ISI
SICI code
1251-8069(1996)323:5<329:TSOTCS>2.0.ZU;2-C
Abstract
We propose a model for the involvement of type I DNA topoisomerases in the separation of the complementary strands of the DNA double-helix, a process which occurs in DNA replication or transcription. Using this model, we introduce a protein friction associated with the strand-pas sing activity of type I DNA topoisomerase. This protein friction is la rge and could contribute significantly to the overall mechanical load opposing the separation process.