CHARACTERIZATION OF POLYMERIC GOLD(I)-CAPTOPRIL COMPLEX USING VISCOSITY AND VARIOUS SPECTROSCOPIC TECHNIQUES

The characterization of polymeric gold(I)-captopril (Aucap)(n) is carr ied out using viscosity, electronic, mass, and C-13, N-15 NMR spectros copy. From viscosity measurements, it is observed that the degree of a ssociation in (Aucap)(n) is much higher than in (Autm)(n). The (Aucap) (n) was further polymerized in the presence of SCN- and SeCN- ions; ho wever, the CN- ion caused the breakdown of the polymer. After a few ho urs of the addition of SeCN- to (Aucap)(n) solution, SeCN- underwent d ecomposition to produce CN- and ''Se'' metal which caused dissociation of the polymer. The mass spectroscopic results showed two characteris tic routes of fragmentation for (Aucap)(n). Electronic spectroscopy in dicated the generation of [Au(CN)(2)](-) at a CN-:(Aucap)(n) ratio gre ater than or equal to 1, whereas C-13, N-15 NMR spectroscopic studies have indicated the detection of [Au(CN)(2)](-) even at a 1:12 ratio of CN-:(Aucap)(n). The C-13 NMR is found to be sensitive to the configur ation of the penultimate captopril moiety.