SEQUENCE-SPECIFIC OLIGODEOXYRIBONUCLEOTIDE CLEAVAGE BY A MAJOR-GROOVE-POSITIONED METAL-BINDING LIGAND TETHERED TO C-5 OF DEOXYURIDINE

Authors
BERGSTROM DE CHEN JY
Citation
De. Bergstrom et Jy. Chen, SEQUENCE-SPECIFIC OLIGODEOXYRIBONUCLEOTIDE CLEAVAGE BY A MAJOR-GROOVE-POSITIONED METAL-BINDING LIGAND TETHERED TO C-5 OF DEOXYURIDINE, Bioorganic & medicinal chemistry letters, 6(18), 1996, pp. 2211-2214
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
18
Year of publication
1996
Pages
2211 - 2214
Database
ISI
SICI code
0960-894X(1996)6:18<2211:SOCBAM>2.0.ZU;2-Z
Abstract
Highly efficient cleavage of the single-stranded oligonucleotide 5'-d( CTGGCTCACAAATACCACTGAGATCTTTTTC)-3' (O1) at nucleotides G20, A21, and G22 was achieved by an iron-bipyridine complex linked to a targeting o ligonucleotide 5'-d(AAA AAG ATC TCA)-3' (O2) through -SCH2CH2NHC(O)- at C5 of a 2'-deoxyuridine (T). Copyright (C) 1996 Elsevier Science L td