O-BENZYL HYDROXYPROLINE AS A BIOISOSTERE FOR PHE-PRO - NOVEL DIPEPTIDE THROMBIN INHIBITORS

Authors
KLEIN SI DENER JM MOLINO BF GARDNER CJ DALISA R DUNWIDDIE CT KASIEWSKI C LEADLEY RJ
Citation
Si. Klein et al., O-BENZYL HYDROXYPROLINE AS A BIOISOSTERE FOR PHE-PRO - NOVEL DIPEPTIDE THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 6(18), 1996, pp. 2225-2230
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
18
Year of publication
1996
Pages
2225 - 2230
Database
ISI
SICI code
0960-894X(1996)6:18<2225:OHAABF>2.0.ZU;2-4
Abstract
A series of analogs were prepared based on the known thrombin inhibito r PPACK, in which the D-Phe-ho dipeptide has been replaced by trans-4- O-benzyl hydroxyproline. One of these analogs is a more potent inhibit or of thrombin, and is more selective, than PPACK itself. Copyright (C ) 1996 Elsevier Science Ltd