PREPARATION OF ARBONYL-N'-[2-NITRO-4(5)-PROPYLTHIOPHENYL]THIOUREA AS PRODRUGS OF ALBENDAZOLE

Authors
HERNANDEZLUIS F CASTILLO R YEPEZMULIA L CEDILLORIVERA R MARTINEZVAZQUEZ G MORALESHURTADO R JUNG HG SANCHEZ M HERNANDEZCAMPOS A VIVEROS N MUNOZ O
Citation
F. Hernandezluis et al., PREPARATION OF ARBONYL-N'-[2-NITRO-4(5)-PROPYLTHIOPHENYL]THIOUREA AS PRODRUGS OF ALBENDAZOLE, Bioorganic & medicinal chemistry letters, 6(18), 1996, pp. 2231-2236
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
18
Year of publication
1996
Pages
2231 - 2236
Database
ISI
SICI code
0960-894X(1996)6:18<2231:POAAP>2.0.ZU;2-8
Abstract
xycarbonyl-N'-(2-nitro-4-propylthiophenyl)thiourea and ycarbonyl-N'-(2 -nitro-5-propylthiophenyl)thiourea, prodrugs of albendazole, have been synthesized. The biotransformation in rats, after oral administration of these prodrugs to albendazole and albendazole sulphoxide, is descr ibed. Copyright (C) 1996 Elsevier Science Ltd