PHYSICAL-TRAINING LIMITS THE FALL OF BLOOD-PRESSURE AND THE ENDOTHELIUM OVERACTIVATION IN ACUTE MYOCARDIAL-INFARCTION

Physical training (PT) is beneficial in cardiovascular diseases associ ated with NO deficiency such as coronary disease, hypertension, etc. H owever, it is not known whether PT can also prevent pathological condi tions associated with excess NO and fall of blood pressure (BP) such a s acute myocardial infarction (AMI). The aim was to compare the effect of AMI on BP and functional state of the endothelium in rats trained by swimming and in untrained animals After AMT, BP fell from 110+/-2 t o 74+/-4 mm Hg (p<0.05), the endothelium-dependent relaxation increase d from 37+/-4 to 66+/-6 % (p<0.05) and the extent of contraction suppr ession by the endothelium was significantly greater than in the contro ls PT itself increased the endothelium-dependent relaxation of rat aor ta but left BP unaffected PT limited the AMI-induced fall of BP to 87/-3 mm Hg, the endothelium- dependent relaxation to 53+/-4 % and preve nted the hyporesponsiveness of the aorta to norepinephrine. We suggest that the protective effect of PT is related to inhibition of inducibl e NO synthase by a negative feedback mechanism.