T. Sladek et al., MORPHOMETRIC CHARACTERISTICS OF CARDIAC-HYPERTROPHY INDUCED BY LONG-TERM INHIBITION OF NO SYNTHASE, Physiological Research, 45(4), 1996, pp. 335-338
Morphometry of cardiomyocytes and capillary domains in the left ventri
cle myocardium was performed in control rats and in rats treated with
nitro-l-arginine methyl eater 50 mg/kg/day p.o. for a period of 8 week
s The myocardial hypertrophy accompanying the NO-deficient hypertensio
n induced by chronic inhibition of NO synthase is characterized by an
increase in thickness of myocardial fibres and by relative rarefaction
of the capillary bed, e.g. an alteration in myocardial structure whic
h is typical for pressure overload hypertrophy.