STUDIES ON THE SYNTHESIS OF CHOLECYSTOKININ A RECEPTOR ANTAGONISTS .4. SYNTHESIS AND CHOLECYSTOKININ A RECEPTOR INHIBITORY ACTIVITIES OF BENZIMIDAZOLE DERIVATIVES

Authors
AJISAWA Y AKAHANE K AKAHANE M SATO K TAMAI T SAITO M TANAKA N KAMATA K KOBAYASHI M
Citation
Y. Ajisawa et al., STUDIES ON THE SYNTHESIS OF CHOLECYSTOKININ A RECEPTOR ANTAGONISTS .4. SYNTHESIS AND CHOLECYSTOKININ A RECEPTOR INHIBITORY ACTIVITIES OF BENZIMIDAZOLE DERIVATIVES, Yakugaku zasshi, 116(9), 1996, pp. 735-747
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Yakugaku zasshi → ACNP
ISSN journal
00316903
Volume
116
Issue
9
Year of publication
1996
Pages
735 - 747
Database
ISI
SICI code
0031-6903(1996)116:9<735:SOTSOC>2.0.ZU;2-R
Abstract
A number of benzimidazole derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to stu dy structure-activity relationships. Significant CCK-A receptor inhibi tory activities were found in the compounds having carboxyl or tetrazo lyl group. As the most preferred compound, dazol-2-yl)-N-(3-methoxypro pyl)-N-pentylglutaramic acid (4g) was selected.