MULTIPLE-SOLVENT SUPPRESSION IN DOUBLE-QUANTUM NMR EXPERIMENTS WITH MAGIC-ANGLE PULSED-FIELD GRADIENTS

Phase-sensitive and absolute-value H-1 double-quantum (DQ) experiments recorded with magic angle pulsed field gradients (PFGs) result in spe ctra with substantial multiple solvent suppression. Although this meth od also results in the suppression of singlet peaks of the molecule of interest, it nevertheless represents a powerful technique for MMR ana lysis. The high sensitivity of the PFG DQ experiments allows their app lication in the NMR structural analysis of diluted samples dissolved i n non-deuterated solvent mixtures. In addition to the suppression of s olvent-solvent DQ coherence, the use of magic angle pulsed field gradi ents results in the suppression of intermolecular DQ coherence between the solvent and the solute.