EFFECT OF 6-MONTH TREATMENT WITH UKRAIN ON EARLY OSTEOPOROSIS INDUCEDBY OVARIECTOMY IN RATS .2. PRELIMINARY STUDIES OF PERIPHERAL-BLOOD PARAMETERS

Studies on Wistar rats have demonstrated that six months after ovariec tomy no changes were observed in peripheral blood morphology other tha n a decreased leukocyte count. A similar effect was noted in the sham- operated group. The present results show that Ukrain treatment started on the second postoperative day and continued every other day for six months significantly increased leukocyte count in comparison with the untreated ovariectomized and sham-operated groups. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) we re also estimated in this study In none of the groups studied was any change of ALT activity noted. The activity of AST was significantly in creased in the sham-operated and untreated ovariectomized rats. After six-month treatment with Ukrain, the activity of this enzyme was signi ficantly decreased in the serum of untreated ovariectomized rats. In r ats pretreated with Ukrain some of the studied parameters of periphera l blood were similar to those of the control group.