EFFECT OF 6-MONTH TREATMENT WITH UKRAIN ON EARLY OSTEOPOROSIS INDUCEDBY OVARIECTOMY IN RATS .3. PRELIMINARY STUDIES OF SOME HORMONE LEVELS

The effect of six-month treatment with Ukrain on the level of some hor mones was investigated in ovariectomized rats. The serum levels of pro lactin, adrenocorticotropic hormone (ACTH), corticosterone, aldosteron e and progesterone were measured by radioimmunoassay (RIA). Six months after ovariectomy, a decrease in prolactin and progesterone levels wa s observed. No changes were noted in the levels of ACTH, corticosteron e and aldosterone in the serum of the ovariectomized animals. On the o ther hand, six-month treatment with Ukrain increased the levels of pro lactin and progesterone and decreased the levels of corticosterone and aldosterone in the ovariectomized rats. The progesterone level in the treated group was four times higher than in the ovariectomized group. The six-month treatment with Ukrain had no effect on the level of ACT H of the serum of the ovariectomized rats. The present results show th at prolonged treatment with Ukrain significantly affects hormone secre tion after ovariectomy.