STUDIES OF THE SYNTHESIS AND ANTITUMOR-AC TIVITY OF S-FLUOROURACIL DERIVATIVES CONTAINING D-AMINOGLUCOSE RESIDUE

This investigation describes the effect of D-aminoglucose on the antit umor activity of 5-fluorouracil. By choosing alpha-amino acids as conn ective group, we have synthesized 4 kinds of 5-fluorouracil derivative s containing D-aminoglucose residue. Their structures were confirmed b y III NMR, IR, UV spectra and elemental analysis. The data of activity against the isolated ehrlich ascites tumor cells in vitro has been ev aluated. The preliminary results show that these compounds all exhibit much better antitumor activity than 5-fluorouracil itself does.