THE RELATION BETWEEN PHYSICIAN-DIAGNOSED SINUSITIS, ASTHMA, AND SKIN-TEST REACTIVITY TO ALLERGENS IN 8-YEAR-OLD CHILDREN

The purpose of this study was to assess the prevalence of sinusitis in a nonselected sample of children, and the relation of sinusitis to al lergic rhinitis (AR), atopy, asthma, and cough in the same population sample. Of 1246 children enrolled at birth in the Tucson Children's Re spiratory Study, 835 were studied at a mean age +/- SD of 8.6 +/- 0.7 years. Questionnaires asking about MD-Sinusitis, MD-AR, MD-Asthma, and cough were completed by parents. Skin tests for seven common aeroalle rgens in the Tucson area had been performed in 630 of the participatin g children at the mean age +/- SD of 6.3 +/- 0.9 years. Prevalence of MD-Sinusitis was 13.1%; 78% of subjects with MD-Sinusitis also had MD- AR. Detailed analysis of the relation between MD-Sinusitis and individ ual environmental allergens tested for showed that only a response to Bermuda grass pollen was significantly associated with MD-Sinusitis af ter controlling for MD-AR [adjusted odds ratio 2.3 (95% CI 1.2-4.3)]. Having MD-Sinusitis was also significantly associated with MD-Asthma a nd cough [odds ratios 3.0 (95% CI 1.8-5.2)] and 2.5 (95% CI 1.6-3.8), respectively]. However, logistic regression demonstrated that, after c ontrolling for MD-AR and skin test reactivity; MD-Sinusitis was no lon ger significantly associated with MD-Asthma or cough. We conclude that MD-Sinusitis is a common condition in childhood. The main independent risk factors in our community for MD-Sinusitis were grass pollen and current MD-AR. MD-Sinusitis was not associated with MD-Asthma or with cough after controlling for skin test reactivity and for MD-AR. (C) 19 96 Wiley-Liss, Inc.