SUCCESSFUL PREDICTIONS OF THE RESIDUAL MOTION OF WEAKLY ASSOCIATED SPECIES AS A FUNCTION OF THE BONDING BETWEEN THEM

We demonstrate the utility of a specific form of a relationship betwee n the bonding (enthalpy change) and restriction in motion (entropy cha nge) for weak associations. This utility is illustrated through an ana lysis of a collection of thermodynamic data for the interaction of mac rocycles with neutral molecules (both in most cases with limited abili ties to change their internal motions) in nonpolar media. By inspectio n of the data in comparison to the trend that would be expected from t his enthalpy/entropy compensation curve, we have successfully identifi ed those points that either represent mistakes in transcription of dat a from the original or incorrect measurements or in the context of the discussion must be represented as associations rather than dissociati ons.