B. Hulin et al., HYPOGLYCEMIC ACTIVITY OF A SERIES OF ALPHA-ALKYLTHIO AND ALPHA-ALKOXYCARBOXYLIC-ACIDS RELATED TO CIGLITAZONE, Journal of medicinal chemistry, 39(20), 1996, pp. 3897-3907
The thiazolidinedione moiety of ciglitazone and its analogues can be r
eplaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. T
he influence of the nature of the R group, the length of the connector
to the aromatic backbone of the molecule, and the stereochemistry hav
e been studied. The most potent compounds have glucose-lowering activi
ty at doses as low as 0.01 mg/kg.