HYPOGLYCEMIC ACTIVITY OF A SERIES OF ALPHA-ALKYLTHIO AND ALPHA-ALKOXYCARBOXYLIC-ACIDS RELATED TO CIGLITAZONE

Authors
HULIN B NEWTON LS LEWIS DM GENEREUX PE GIBBS EM CLARK DA
Citation
B. Hulin et al., HYPOGLYCEMIC ACTIVITY OF A SERIES OF ALPHA-ALKYLTHIO AND ALPHA-ALKOXYCARBOXYLIC-ACIDS RELATED TO CIGLITAZONE, Journal of medicinal chemistry, 39(20), 1996, pp. 3897-3907
Citations number
48
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
39
Issue
20
Year of publication
1996
Pages
3897 - 3907
Database
ISI
SICI code
0022-2623(1996)39:20<3897:HAOASO>2.0.ZU;2-3
Abstract
The thiazolidinedione moiety of ciglitazone and its analogues can be r eplaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. T he influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry hav e been studied. The most potent compounds have glucose-lowering activi ty at doses as low as 0.01 mg/kg.