ITASETRON (DAU-6215) PREVENTS AGE-RELATED MEMORY DEFICITS IN THE RAT IN A MULTIPLE-CHOICE AVOIDANCE TASK

Authors
PITSIKAS N BORSINI F
Citation
N. Pitsikas et F. Borsini, ITASETRON (DAU-6215) PREVENTS AGE-RELATED MEMORY DEFICITS IN THE RAT IN A MULTIPLE-CHOICE AVOIDANCE TASK, European journal of pharmacology, 311(2-3), 1996, pp. 115-119
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
311
Issue
2-3
Year of publication
1996
Pages
115 - 119
Database
ISI
SICI code
0014-2999(1996)311:2-3<115:I(PAMD>2.0.ZU;2-N
Abstract
The effects of itasetron )-2,3-dihydro-2-oxo-1H-benzimidazole-1-carbox amide hydrochloride), a 5-HT3 receptor antagonist, on discrete memory abilities of the aged rat were assessed by using the multiple choice a voidance behavioral task. Chronic treatment with itasetron (i.p., 10 m u g/kg, b.i.d., for three consecutive weeks), but not with vehicle, si gnificantly improved retention abilities of the aged rats in this memo ry test. These results further support the important role of this 5-HT 3 receptor antagonist in counteracting age-related memory degeneration in rodents.