PRIMARY EXTRANODAL LYMPHOMAS OF WALDEYERS RING, STAGE IE AND IIE - LONG-TERM SURVIVAL AFTER CHEMOTHERAPY COMBINED WITH RADIOTHERAPY

We reviewed 45 cases of Waldeyer's ring lymphomas (25 stage IE, 20 IIE ): 73% had high-grade histology according to Kiel's classification. Fo urteen patients received radiotherapy alone and 31 chemotherapy, combi ned with radiotherapy in 28. Complete remission rate was 95% and relap se rate 32%. At 8 years overall disease-related survival (DRS) and eve nt-free survival (EFS) were 69% and 57% respectively. Combined treatme nt provided both significantly better DRS (82% vs 42%) and EFS (76% vs 25%) than radiotherapy alone. Most of the patients with high-grade hi stology (26/33) received the combined treatment and this subgroup achi eved a long-term EFS of 78%. Both DRS and EFS were also significantly longer in patients under 60. At multivariate analysis favorable progno stic factors were lower age for DRS and combined treatment for EFS.