INDUCTION OF INTERLEUKIN (IL)-1-BETA AND IL-8 MESSENGER-RNA EXPRESSION IN PORCINE MACROPHAGES BY LIPOPOLYSACCHARIDE FROM SERPULINA-HYODYSENTERIAE

Authors
SACCO RE NIBBELINK SK BAARSCH MJ MURTAUGH MP WANNEMUEHLER MJ
Citation
Re. Sacco et al., INDUCTION OF INTERLEUKIN (IL)-1-BETA AND IL-8 MESSENGER-RNA EXPRESSION IN PORCINE MACROPHAGES BY LIPOPOLYSACCHARIDE FROM SERPULINA-HYODYSENTERIAE, Infection and immunity, 64(10), 1996, pp. 4369-4372
Citations number
19
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
10
Year of publication
1996
Pages
4369 - 4372
Database
ISI
SICI code
0019-9567(1996)64:10<4369:IOI(AI>2.0.ZU;2-M
Abstract
Lipopolysaccharide (LPS) is a classic inducer of inflammatory cytokine s and is a key virulence factor for most gram-negative pathogens. The effect of phenol-water (LPS) and butanol-water (endotoxin) extracts fr om Serpulina hyodysenteriae on inflammatory cytokine mRNA expression f rom porcine alveolar macrophages was investigated. The LPS and endotox in extracts from S. hyodysenteriae induced a dose-dependent expression of interleukin 1 beta (IL-1 beta) and IL-8 which was weak compared wi th the responses induced by Escherichia coli LPS. In addition, the spi rochetal extracts induced no detectable upregulation of mRNA expressio n for either IL-6 or tumor necrosis factor alpha.