Ay. Christian et al., HOST IMMUNE-RESPONSE TO VESICULAR STOMATITIS-VIRUS INFECTION OF THE CENTRAL-NERVOUS-SYSTEM IN C57BL 6 MICE/, Viral immunology, 9(3), 1996, pp. 195-205
In this report, the kinetics of cellular inflammatory changes in the b
rains of vesicular stomatitis virus (VSV)-infected C57BL/6 (B6) mice w
as determined. The behavior and survival rate of infected B6 were care
fully monitored each day, Infectious viral titers and VSV antigen dist
ribution were determined at several time points during the course of i
nfection, Strong activation of both astrocytes and microglia was obser
ved after VSV infection, Induction of type II nitric oxide synthase (i
NOS) was detected in activated microglia in the olfactory bulb (OB) st
arting at day 4 postinfection, Induced expression of major histocompat
ibility complex (MHC) molecules and rapid infiltration of both T cells
and natural killer (NK) cells were detected in the VSV-infected CNS,
Collectively, these data indicate that the response to CNS infection i
n B6 mice, which is often primarily Th1 in characteristics, is compara
ble to BALB/c mice, a strain that often shows a Th2-dominated immune r
esponse.