IMMUNOCYTOCHEMICAL DETECTION OF ISOLATED EPITHELIAL TUMOR-CELLS IN BONE-MARROW OF PATIENTS WITH PANCREATIC-CARCINOMA

Authors
THORBAN S RODER JD PANTEL K SIEWERT R
Citation
S. Thorban et al., IMMUNOCYTOCHEMICAL DETECTION OF ISOLATED EPITHELIAL TUMOR-CELLS IN BONE-MARROW OF PATIENTS WITH PANCREATIC-CARCINOMA, The American journal of surgery, 172(3), 1996, pp. 297-298
Citations number
7
Categorie Soggetti
Surgery
Journal title
The American journal of surgery → ACNP
ISSN journal
00029610
Volume
172
Issue
3
Year of publication
1996
Pages
297 - 298
Database
ISI
SICI code
0002-9610(1996)172:3<297:IDOIET>2.0.ZU;2-Q
Abstract
Epithelial cells in the bone marrow of 42 patients with pancreatic car cinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantl y associated with cytokeratin-positivity in bone marrow. The presence of these cells is indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadj uvant therapy.