REGIOCHEMISTRY IN ADDITION OF GRIGNARD-REAGENTS TO N,N'-DIBENZYLATED 2-PURINONES

Authors
ANDRESEN G GUNDERSEN LL RISE F
Citation
G. Andresen et al., REGIOCHEMISTRY IN ADDITION OF GRIGNARD-REAGENTS TO N,N'-DIBENZYLATED 2-PURINONES, Tetrahedron, 52(40), 1996, pp. 12979-12992
Citations number
53
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
40
Year of publication
1996
Pages
12979 - 12992
Database
ISI
SICI code
0040-4020(1996)52:40<12979:RIAOGT>2.0.ZU;2-0
Abstract
1,3-, 1,7-,1,9- and 3,7-dibenzylpurin-2-one form stable adducts when r eacted with Grignard reagents. Reaction took place in the purine 6- or 8-position, and substantial differences in the regiochemical outcome of the reactions were found among the isomers. Several new classes of purinones are described here for the first time. The structure elucida tions of the products were accomplished by HETCOR, COLOC, GA-HMQC and GA-HMBC NMR spectroscopy. Copyright (C) 1996 Elsevier Science Ltd