REVIEW - CALCIUM-ANTAGONISTS AND DIURETICS A USEFUL COMBINATION IN THE MANAGEMENT OF HYPERTENSION

The use of the combination of a calcium antagonist with a thiazide diu retic for the treatment of hypertension has been the subject of much d ebate over a number of years. Early studies, with few subjects, demons trated little benefit, but more recent research using larger numbers o f subjects has shown quite clear additional antihypertensive effects o f this combination. Combination therapy has an important role in the t reatment of patients who do not respond to monotherapy, and the combin ation of a calcium antagonist and thiazide diuretic may be useful in t he successful treatment of these patients.