NEW PHARMACOLOGICAL STRATEGIES FOR ACUTE NEURONAL INJURY

Authors
LUER MS RHONEY DH HUGHES M HATTON J
Citation
Ms. Luer et al., NEW PHARMACOLOGICAL STRATEGIES FOR ACUTE NEURONAL INJURY, Pharmacotherapy, 16(5), 1996, pp. 830-848
Citations number
242
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacotherapy → ACNP
ISSN journal
02770008
Volume
16
Issue
5
Year of publication
1996
Pages
830 - 848
Database
ISI
SICI code
0277-0008(1996)16:5<830:NPSFAN>2.0.ZU;2-K
Abstract
The number of new drugs for treating neurotrauma is rapidly expanding. Emerging theories regarding the mechanisms of secondary neuronal inju ry provide the scientific basis for evaluating these new agents. Some of the most promising mechanisms for intervention are ionotropic chann el antagonism, inhibition of lipid peroxidation, and neurotrophic fact or augmentation. Many of these new agents are undergoing clinical tria ls to establish their roles in therapy.