MOLECULAR CYTOGENETICS OF T(12-21)(P13-Q22)

Authors
BERNARD OA ROMANA SP POIREL H BERGER R
Citation
Oa. Bernard et al., MOLECULAR CYTOGENETICS OF T(12-21)(P13-Q22), Leukemia & lymphoma, 23(5-6), 1996, pp. 459
Citations number
41
Categorie Soggetti
Hematology
Journal title
Leukemia & lymphoma → ACNP
ISSN journal
10428194
Volume
23
Issue
5-6
Year of publication
1996
Database
ISI
SICI code
1042-8194(1996)23:5-6<459:MCOT>2.0.ZU;2-P
Abstract
The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangem ent of B-cell lineage childhood acute lymphoblastic leukemia (ALL) whi ch fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22 , respectively. The crucial chimeric gene, TEL AML1, is transcribed fr om the der(21) and encodes the 336 NH2 aminoacids of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated wi th loss of the normal, untranslocated TEL allele. These various aspect s are presented here.