CEREBRAL URIC-ACID INCREASES FOLLOWING EXPERIMENTAL TRAUMATIC BRAIN INJURY IN RAT

Following traumatic brain injury (TBI), cortical and thalamic areas we re analyzed histologically and by high-performance liquid chromatograp hy with electrochemical detection for uric acid at various survival ti mes. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegen eration was found not only in cortex but also in the anteroventral tha lamus. These data suggest that as in stroke, uric acid measurements ma y be a convenient and sensitive method for measuring peroxidative stat us in TBI.