THE EFFECTS OF VERAPAMIL AND FLUNARIZINE ON EPILEPTIFORM ACTIVITY-INDUCED BY BICUCULLINE AND LOW MG2+ IN NEOCORTICAL TISSUE OF EPILEPTIC AND PRIMARY NONEPILEPTIC PATIENTS

Authors
STRAUB H KOHLING R LUCKE A FAUTECK JD SPECKMANN EJ MOSKOPP D WASSMANN H TUXHORN I WOLF P PANNEK H OPPEL F
Citation
H. Straub et al., THE EFFECTS OF VERAPAMIL AND FLUNARIZINE ON EPILEPTIFORM ACTIVITY-INDUCED BY BICUCULLINE AND LOW MG2+ IN NEOCORTICAL TISSUE OF EPILEPTIC AND PRIMARY NONEPILEPTIC PATIENTS, Brain research, 733(2), 1996, pp. 307-311
Citations number
13
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
733
Issue
2
Year of publication
1996
Pages
307 - 311
Database
ISI
SICI code
0006-8993(1996)733:2<307:TEOVAF>2.0.ZU;2-M
Abstract
In human neocortical slices the specific L-type calcium channel blocke r verapamil had been shown to be antiepileptic in the low Mg2+-model o f epilepsy. The present investigation demonstrated: (1) verapamil exer ted also an antiepileptic effect on epileptiform field potentials (EFP ) induced by the GABA(A)-antagonist bicuculline. (2) The unspecific ca lcium channel modulator flunarizine, which in contrast to verapamil pe netrates the blood-brain barrier, depressed EFP in the low Mg2+-model and in the bicuculline model. (3) There was no significant difference in the antiepileptic efficacy of verapamil and flunarizine in epilepti c (epilepsy surgery) and primary non-epileptic (tumor surgery) neocort ical slices.