V. Movsesyan et al., DOWN-REGULATION OF CYCLIN-F LEVELS DURING NERVE GROWTH FACTOR-INDUCEDDIFFERENTIATION OF PC12 CELLS, Experimental cell research, 227(2), 1996, pp. 203-207
Treatment with nerve growth factor (NGF) produces a marked decrease of
cyclin F levels in PC12EY cells. This decrease is prevented by the si
multaneous addition of K-252a. A smaller decrease is observed when the
cells are treated with fibroblast growth factor, but the addition of
epidermal growth factor has no comparable effect; Time course studies
show that the decrease in cyclin F precedes the changes produced by NG
F in the distribution of cells within the cell cycle. The data suggest
that cyclin F is involved in NGF-mediated cell cycle events during th
e differentiation of PC12EY cells. (C) 1996 Academic Press, Inc.