V. Castagne et al., NEUROTOXICOLOGY AND AMINO-ACID INTAKE DURING DEVELOPMENT - THE CASE OF THREONINE, Pharmacology, biochemistry and behavior, 55(4), 1996, pp. 653-662
The development of the central nervous system is highly dependent on a
n adequate supply of nutrients. In particular, protein and amino acid
availability is of major concern during gestation and in early postnat
al life. Numerous data have been published on some amino acids directl
y involved in brain functions as neurotransmitters or indirectly as pr
ecursors of neurotransmitters, but scant information is available on t
he possible consequences of hyperthreoninemia, a phenomenon repeatedly
noted in clinical reports. The results of neurochemical and behaviora
l studies in the developing rat suggest that despite numerous possible
effects of threonine on brain constituents, moderate hyperthreoninemi
a does not impair markedly the development of the central nervous syst
em. Copyright (C) 1996 Elsevier Science Inc.