CLONING OF GENES DIFFERENTIALLY EXPRESSED IN THE CEREBELLUM DURING POSTNATAL RAT DEVELOPMENT

To identify genes differentially expressed in the developing rat cereb ellum, a subtractive cDNA cloning procedure, followed by differential screening, was used. Four novel genes, MB, MF, 3E7, and 3C6, the trans criptional activity of which changed by a factor of five during cerebe llar development, were isolated. The genes obtained were differentiall y expressed in different regions of the central nervous system. Variat ions in the levels of corresponding transcripts in the brain cortex an d cerebellum were also recorded during postnatal rat development.