POSSIBLE ASSOCIATION BETWEEN THE HETEROZY GOSITY LEVEL OF BIOCHEMICALGENE MARKERS IN PATIENTS WITH PULMONARY PATHOLOGY

The comparative heterozygosity level was estimated in patients sufferi ng from squamous epithelial lung cancer (SELC) and in patients with ch ronic pneumonia with bronchiectases. To estimate heterozygosity, seven loci, reflecting normal diversity in human populations, were used (HP , TF, GC, PI, GL01, ACP1, PCM1). SELC patients with an uncomplicated p ostoperative period were distinguished by an increase in the level of observed heterozygosity (H-0 = 0.3916) in comparison with the theoreti cally expected value (H-e = 0.4361). Patients having chronic pneumonia with bronchiectases with a complicated postoperative period were dist inguished by an increase in the observed and expected level of heteroz ygosity (H-0 = 0.3737, H-e = 0.3837) in comparison with that in the pa tient cohort with an uncomplicated postoperative period. The Wright's fixation index had a high value in the SELC cohort with an uncomplicat ed postoperative period (F = 0.1073) and a low value in patients with complicated cases (0.0048),witnessing the polar divergence of those pa tients from the total group of patients (0.0598) and the control (0.03 88). The D criterion, reflecting deviation from the maximum heterozygo sity level, distinguished the SELC patient cohort with a complicated p ostoperative period from patients with uncomplicated cases by the HP, GC, and ACP1 loci. The D criterion distinguished the SELC patients fro m the healthy control groups by the PGM1 locus.