THE ACCUMULATION IN LYSOSOMES OF THE ANIONIC DETERGENT LINEAR ALKYLBENZENE SULFONATE

Authors
BRAGADIN M PERIN G RACCANELLI S MANENTE S
Citation
M. Bragadin et al., THE ACCUMULATION IN LYSOSOMES OF THE ANIONIC DETERGENT LINEAR ALKYLBENZENE SULFONATE, Environmental toxicology and chemistry, 15(10), 1996, pp. 1749-1751
Citations number
14
Categorie Soggetti
Toxicology,"Environmental Sciences",Chemistry
Journal title
Environmental toxicology and chemistry → ACNP
ISSN journal
07307268
Volume
15
Issue
10
Year of publication
1996
Pages
1749 - 1751
Database
ISI
SICI code
0730-7268(1996)15:10<1749:TAILOT>2.0.ZU;2-E
Abstract
This in vitro study provides evidence that the anionic detergent linea r alkylbenzene sulfonate (LAS) enters energized lysosomes from rat liv er. Because LAS is lipophilic and negatively charged, the uptake is du e to the presence of a positive inside potential induced by energizati on of lysosomes. This accumulation could explain some damage caused by sublethal doses of detergent in some aquatic species, as it has been found that LAS inhibits lysosomal enzymes such as acid phosphatase and alkaline phosphatase.