we consider the problem of sharp-optimal estimation of a response func
tion f(x) in a random design nonparametric regression under a general
model where a pair of observations (Y, X) has a joint density p(y, x)
= p(y\f(x))pi(x). We wish to estimate the response function with optim
al minimax mean integrated squared error convergence as the sample siz
e tends to infinity. Traditional regularity assumptions on the conditi
onal density p(y\theta) assumed for parameter theta estimation are suf
ficient for sharp-optimal nonparametric risk convergence al well as fo
r the existence of the best constant and rate of risk convergence. Thi
s best constant is a nonparametric analog of Fisher information. Many
examples are sketched including location and scale families, censored
data, mixture models and some well-known applied examples. A sequentia
l approach and some aspects of experimental design are considered as w
ell.