RELIABILITY OF IONIC CURRENT MEASUREMENTS IN RANVIER NODES

A mathematical formalism was developed comprising four performance par ameters to analyse electronic feedback systems for voltage clamp measu rements in myelinated nerve fibres. The effects of the so-called Schmi dt-Lanterman incisures and of the nodal series resistance were of part icular interest here. Starting from passive standard data from myelina ted nerve fibres, we calculated the frequency dependence of the above mentioned parameters for the measuring systems according to Nonner, to Dodge and Frankenhaeuser, and to Bohuslavizki and coworkers. It turne d out that the latter system is clearly preferable to the two remainin g systems for ionic current measurements in Ranvier nodes.