PRECONCENTRATION AND MICROREACTION TECHNOLOGY ONLINE WITH CAPILLARY ELECTROPHORESIS

The techniques of capillary electrophoresis (CE) are often the methods of choice for the analysis of complex mixtures of chemically similar molecules. Their applicability to studies across many diverse discipli nes is quite remarkable. However, poor concentration limits of detecti on of CE methods often preclude their use for the analysis of dilute a nalyte mixtures. This limitation has been addressed by the development of analyte concentrator and membrane preconcentration cartridges. The se devices are used to insert an appropriate adsorptive phase into the inlet of the CE capillary, to enable the analysis of sample amounts t hat are in vast excess of the total capillary volume, An ability to pe rform on-line microreactions is a further advantage afforded by these devices. In this report, we present all attempted approaches at on-lin e preconcentration and microreaction with analyte separation by CE. We discuss the potential merits of each technique and describe our views of the future developments of analyte concentrator and membrane preco ncentration technologies.