ANTIFUNGAL THERAPEUTICS IN THE DERMATOPHY TIC DISEASE (CHRONIC GRANULOMATOUS DERMATOPHYTOSIS) - FAILURE OF GRISEOFULVIN, ITRACONAZOLE, KETOCONAZOLE AND TERBINAFINE

The ''dermatophytic disease'' (chronic granulomatous dermatophytosis) is a rare, severe affection caused by can non dermatophytes. A genetic ally predisposed ground could explain the frequent failure of antifung al therapeutics. We report one case, from a 42-year-old male patient, with characteristic dermatophytic disease due to Trichophyton violaceu m. Despite 8 months of griseofulvin, 12 months of itraconazole, 26 mon ths of ketoconazole and 1,5 months of terbinafine, the therapeutic esc ape was evident leading to septicemia and death. The correction of the immunodeficient ground combined with antifungals could be the best th erapeutic.