OVEREXPRESSION OF E2F1 IN ASTROCYTES LEADS TO NEOPLASTIC TRANSFORMATION AND CHANGES IN EXPRESSION OF RETINOBLASTOMA FAMILY MEMBERS

Authors
MIYAJIMA M NORNES HO SATO K NEUMAN T
Citation
M. Miyajima et al., OVEREXPRESSION OF E2F1 IN ASTROCYTES LEADS TO NEOPLASTIC TRANSFORMATION AND CHANGES IN EXPRESSION OF RETINOBLASTOMA FAMILY MEMBERS, Journal of neuroscience research, 46(1), 1996, pp. 108-113
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Journal of neuroscience research → ACNP
ISSN journal
03604012
Volume
46
Issue
1
Year of publication
1996
Pages
108 - 113
Database
ISI
SICI code
0360-4012(1996)46:1<108:OOEIAL>2.0.ZU;2-9
Abstract
Overexpression of mouse E2F1 full-length but not truncated forms resul ts in neoplastic transformation of astrocytes in vitro, This neoplasti c transformation is accompanied with changes in cell morphology and ex pression of cell cycle regulators, Transformed astrocytes have higher expression of cdk2, pRb, and p107 than control astrocytes, However, ex pression of glial fibrillary acidic protein (GFAP) and p130 is reduced in transformed astrocytes. (C) 1996 Wiley-Liss, Inc.