J. Kondoh et al., ENZYME BIOSENSOR BASED ON SURFACE-ACOUSTIC-WAVE DEVICE, Electronics & communications in Japan. Part 2, Electronics, 79(7), 1996, pp. 69-75
In a shear horizontal surface acoustic wave (SH-SAW) propagating throu
gh a piezoelectric crystal, shear wave and piezoelectric potential due
to piezoelectric effect are combined. SH-SAW can be useful for chemic
al sensing in the liquid phase. When the load liquid and propagation s
urface are in contact, the change in the electrical property of the li
quid can be detected due to the acoustoelectric interaction. This pape
r describes a new type of acoustoelectric biosensor with an enzyme mem
brane on the SH-SAW propagating plane for detecting pH change in liqui
d and reports that the SH-SAW enzyme sensor with urease is highly sens
itive in detecting urea. In addition, this paper describes the detecti
on limit, aging characteristic, and high sensitivity of the detector.