STEREOSELECTIVE PUDOVIK REACTION OF 5,6-B ETHYL)-2-OXO-1,3,2-LAMBDA(4)-DIAZAPHOSPHORIN-4-ONE WITH A 3-THIAZOLINE AND MPL-CHROMATOGRAPHIC ISOLATION OF THE MAJOR DIASTEREOMER

Authors
GROGER H WILKEN J MARTENS J NEDA I PINCHUK V THONNESSEN H JONES PG SCHMUTZLER R
Citation
H. Groger et al., STEREOSELECTIVE PUDOVIK REACTION OF 5,6-B ETHYL)-2-OXO-1,3,2-LAMBDA(4)-DIAZAPHOSPHORIN-4-ONE WITH A 3-THIAZOLINE AND MPL-CHROMATOGRAPHIC ISOLATION OF THE MAJOR DIASTEREOMER, Zeitschrift fur Naturforschung. B, A journal of chemical sciences, 51(9), 1996, pp. 1305-1312
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Zeitschrift fur Naturforschung. B, A journal of chemical sciences → ACNP
ISSN journal
09320776
Volume
51
Issue
9
Year of publication
1996
Pages
1305 - 1312
Database
ISI
SICI code
0932-0776(1996)51:9<1305:SPRO5E>2.0.ZU;2-R
Abstract
The modified Pudovik reaction of 6-benzo-2H-1-methyl-3-(2'-chloroethyl )-2-oxo-1,3,2 lambda(4)-diazaphosphorin-4-one with a 3-thiazoline furn ishing the corresponding 2'-chloroethyl)-2-oxo-2-(3-thiazolidin-4-yl)- 1,3,2 lambda(4)-diazaphosphorin-4-one 4 and the medium pressure liquid column chromatographical (MPLC) isolation of the major diastereomer i s described. The relative stereochemistry at the centres P1 and C1 was determined by X-ray structure determination of three racemic modifica tions (a total of seven independent molecules).