INCLUSION COMPLEX-FORMATION OF ANTISENSE NUCLEOTIDES WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN

Authors
CSERHATI T FORGACS E SZEJTLI J
Citation
T. Cserhati et al., INCLUSION COMPLEX-FORMATION OF ANTISENSE NUCLEOTIDES WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN, International journal of pharmaceutics, 141(1-2), 1996, pp. 1-7
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
141
Issue
1-2
Year of publication
1996
Pages
1 - 7
Database
ISI
SICI code
0378-5173(1996)141:1-2<1:ICOANW>2.0.ZU;2-K
Abstract
The interaction between 26 nucleoside derivatives and hyroxypropyl-bet a-cyclodextrin (HPBCD) was determined by charge-transfer chromatograph y. HPBCD interacted with each nucleoside decreasing the lipophilicity of the guest molecules. Both sterical (specific hydrophobic surface ar ea) and hydrophobicity parameters of nucleosides influenced the streng th of interaction. Substituents with longer alkyl chain considerably i ncreased the strength af interaction whereas the effect of double or t riple bond in the chain was negligible.