IN-VITRO DRUG-RELEASE FROM POROUS CELLULOSE MATRICES

Authors
GREN T BJERRE C CAMBER O RAGNARSSON G
Citation
T. Gren et al., IN-VITRO DRUG-RELEASE FROM POROUS CELLULOSE MATRICES, International journal of pharmaceutics, 141(1-2), 1996, pp. 53-62
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
141
Issue
1-2
Year of publication
1996
Pages
53 - 62
Database
ISI
SICI code
0378-5173(1996)141:1-2<53:IDFPCM>2.0.ZU;2-Z
Abstract
Drugs of different solubilities were incorporated into porous cellulos e matrices (PCMs) by solvent evaporation. The rate of release of the d rugs from the PCMs was found to decrease with increasing drug concentr ation and decreasing drug solubility. At low or moderate drug concentr ations, the release rate remained moderately high except for drugs of very low solubility. The mechanisms controlling release rate appeared to include diffusion within the matrix but may be more complex.