S. Malamataris et al., APPARENT COMPRESSIVE ELASTIC-MODULUS AND STRENGTH ISOTROPY OF COMPACTS FORMED FROM BINARY POWDER MIXES, International journal of pharmaceutics, 141(1-2), 1996, pp. 101-108
An apparent compressive Young's modulus of elasticity of cylindrical t
ablets, produced from binary powder mixtures compressed at two tableti
ng rates, was compared with the tensile strength isotropy expressed as
the ratio of axial to radial tensile strength. The binary powder mixt
ures comprised materials which differ in yield pressure and in the ext
ent of elastic deformation, plastic flow and fragmentation during thei
r consolidation. A log-linear correlation was found between the appare
nt Young's modulus of elasticity of the tablets and the tensile streng
th isotropy, indicating that they were similarly related to the compos
ition of the tablets. However, some differences in the effect of compr
ession rate were evident. Thus, apparent Young's modulus varied with c
ompression rate, depending on the principal consolidation mechanism of
the component materials. In contrast, the tensile strength isotropy w
as virtually unaffected by an increase in the compression rate except
for mixtures of paracetamol with Avicel which showed a slight decrease
in isotropy. The tensile strength isotropy - a measure of the interpa
rticle bonding isotropy - of the tablets could be improved by increasi
ng the apparent Young's modulus, through the incorporation of a compon
ent, the particles of which undergo fragmentation or possess a high yi
eld pressure.