STUDY OF BETA-CYCLODEXTRIN AND ETHYLATED BETA-CYCLODEXTRIN SALBUTAMOLCOMPLEXES, IN-VITRO EVALUATION OF SUSTAINED-RELEASE BEHAVIOR OF SALBUTAMOL

Solid complexes of salbutamol with beta-cyclodextrin (beta-CD) and dif ferent batches of ethylated beta-cyclodextrin (Et-beta-CD) in a 1 : 1 molar ratio were prepared by the freeze-drying method. Inclusion compl exation of salbutamol with all the CD used was confirmed in the solid state by differential scanning calorimetry (DSC), and in aqueous solut ion by circular dichroism analysis and electrospray mass spectrometry (ES-MS). The dissolution rate of salbutamol from the inclusion complex es was determined in water. We discuss the behaviour of the dissolutio n profiles obtained, since the Et-beta-CD complexes displayed a slower release of salbutamol compared with the beta-CD complex.