PREPARATION, CHARACTERIZATION AND TRANSFORMATION OF TERFENADINE POLYMORPHIC FORMS

Authors
SALEM MS PILLAI GK NABULSI L ALKAYSI HN ARAFAT TA MALOOH AA SALEH M BADWAN AA
Citation
Ms. Salem et al., PREPARATION, CHARACTERIZATION AND TRANSFORMATION OF TERFENADINE POLYMORPHIC FORMS, International journal of pharmaceutics, 141(1-2), 1996, pp. 257-259
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
141
Issue
1-2
Year of publication
1996
Pages
257 - 259
Database
ISI
SICI code
0378-5173(1996)141:1-2<257:PCATOT>2.0.ZU;2-T
Abstract
Polymorphic modifications of terfenadine as well as solvates from vari ous solvents have been prepared and characterised by X-ray powder diff raction (XRPD), infrared (IR) spectroscopy, differential scanning calo rimetry (DSC) and thermogravimetric analysis. Crystallization of terfe nadine from n-alkanols, except methanol and ethanol, resulted in the s table polymorph 1 (m.p. 151 degrees C) while the iso-alkanols yielded the corresponding solvates. Water content, temperature of incubation a nd duration were found to have significant effect on transformation.