SPECIFIC-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE MEDIATED BY SOULATTROLIDE, A COUMARIN ISOLATED FROM THE LATEX OF CALOPHYLLUM-TEYSMANNII

Authors
PENGSUPARP T SERIT M HUGHES SH SOEJARTO DD PEZZUTO JM
Citation
T. Pengsuparp et al., SPECIFIC-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE MEDIATED BY SOULATTROLIDE, A COUMARIN ISOLATED FROM THE LATEX OF CALOPHYLLUM-TEYSMANNII, Journal of natural products, 59(9), 1996, pp. 839-842
Citations number
37
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
9
Year of publication
1996
Pages
839 - 842
Database
ISI
SICI code
0163-3864(1996)59:9<839:SOHTR>2.0.ZU;2-B
Abstract
Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii lat ex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 mu M. Inhibition was remarkably specific, wi th no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.